L-2-HGA (L-2-hydroxyglutaric aciduria) in Staffordshire Bull Terriers is a neurometabolic disorder

L-2-HGA affects the central nervous system, with clinical signs usually apparent between 6 months and one year (although they can appear later). Symptoms include epileptic seizures, "wobbly" gait, tremors, muscle stiffness as a result of exercise or excitement and altered behaviour.

CLEAR: the dog has 2 copies of the normal gene and will neither develop L-2-HGA, nor pass a copy of the L-2-HGA gene to any of its offspring.

CARRIER: the dog has one copy of the normal gene and one copy of the mutant gene that causes L-2-HGA. It will not develop L-2-HGA but will pass on the L-2-HGA gene to 50% (on average) of its offspring.

AFFECTED: the dog has two copies of the L-2-HGA mutation and is affected with L-2-HGA. It will develop L-2-HGA at some stage during its lifetime, assuming it lives to an appropriate age

Carriers can still be bred to clear dogs. On average, 50% of such a litter will be clear and 50% carriers; there can be no affecteds produced from such a mating. Pups which will be used for breeding can themselves be DNA tested to determine whether they are clear or carriers.


Primary hereditary cataract (HC) is one of the most common disorders in purebred dogs and is a leading cause of blindness

Hereditary forms of canine cataract are also often referred to as "primary cataracts," to distinguish them from "secondary cataracts" that follow other eye diseases, such as progressive retinal atrophy, retinal dysplasia, and glaucoma.

It is known that HC is inherited by an automal recessive path (i.e. both parents must be carriers of the defective gene to produce affected offspring). HC is a progressive condition and this means that although a puppy is not born with cataracts they will start to develop at a juvenile age. (maybe from 8 months).

CLEAR: Normal genes and therefore unable to pass HC onto any offspring

CARRIER: The dog has one copy of the normal gene and one copy of the mutant gene. It will pass on the mutant gene to 50% (on average) of its offspring

AFFECTED: Affected by the disease. (Therefore has received a copy of the gene from BOTH parents and WILL develop HC)

A carrier animal will NEVER develop cataracts themselves. If mated to a non carrier animal, a percentage of the pups could also be carriers and a percentage clear. If mated to another carrier, a percentage will be AFFECTED, a percentage carriers and a percentage clear.



Contact Details

Kylie Rickard
Near Bundaberg, QLD, Australia
Phone : 0421364919
Email : [email protected]